| CASE REPORT |
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| Year : 2015 | Volume
: 20
| Issue : 2 | Page : 80-81 |
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Unusual manifestation of therapeutic dose of lithium as syndrome of irreversible lithium-effectuated neurotoxicity
Hemendra Singh1, Sundernag Ganjekar1, Anand Kalegowda2, Murali Thyloth1
1 Department of Psychiatry, M.S. Ramaiah Medical College and Hospitals, Bengaluru, Karnataka, India
2 Department of Radiodiagnosis, M.S. Ramaiah Medical College and Hospitals, Bengaluru, Karnataka, India
Correspondence Address:
Hemendra Singh
Department of Psychiatry, M.S. Ramaiah Medical College, Bengaluru - 560 054, Karnataka
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/0971-8990.174600
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Lithium is a commonly used mood stabilizer. However, because lithium has a low therapeutic index, lithium-induced drug toxicity is frequently seen in clinical practice. While most side effects of lithium use reverse after the drug is discontinued, in rare cases patients develop a persistent neurological side effect known as a syndrome of irreversible lithium-effectuated neurotoxicity (SILENT). We report a case where the patient developed SILENT even when given a therapeutic dose of lithium. Our case also supports the biological mechanism of SILENT, which involves demyelination at multiple sites in the brain. |
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