Journal of Mental Health and Human Behaviour

DR. G C BORAL AWARD PAPER
Year
: 2017  |  Volume : 22  |  Issue : 1  |  Page : 14--20

Role of Vitamin D supplementation in patients with depressive disorders and hypovitaminosis D: A longitudinal study


Naresh Nebhinani1, Praveen Sharma2, Navratan Suthar1 
1 Department of Psychiatry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
2 Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India

Correspondence Address:
Naresh Nebhinani
Department of Psychiatry, All India Institute of Medical Sciences, Jodhpur - 342 005, Rajasthan
India

Background and Aim: Available literature is inconsistent for the role of Vitamin D supplementation in depression. With scarcity of Indian data, we aimed to study Vitamin D deficiency in patients with depression, its association with time to remission and role of Vitamin D supplementation. Methods: A total of 158 outpatients with depressive disorders were consecutively assessed for Vitamin D deficiency, severity of depression, physical activity, and nutritional habits and followed-up for 1 year. Eighty-seven patients completed follow-up for 1 year (55% retention). Results: Mean serum Vitamin D level was 11.9 ng/ml and the majority of patients (85%) had Vitamin D deficiency (<20 ng/mL). Significant predictors of hypovitaminosis D were being female, unemployed or homemaker, from nuclear family and with a smaller height. Vitamin D deficient patients took significantly longer time in remission than nondeficient patients (2.86 months vs. 1.35 months, P= 0.006). Patients with Vitamin D deficiency received Vitamin D supplementation and subsequently their time to remission was comparable to nondeficient group. Conclusions: The majority of patients had Vitamin D deficiency, took a longer time to remission and reported improvement with Vitamin D supplementation. It signifies the importance of treating hypovitaminosis D for effective management of depression, to avoid delay in response, and incomplete remission.


How to cite this article:
Nebhinani N, Sharma P, Suthar N. Role of Vitamin D supplementation in patients with depressive disorders and hypovitaminosis D: A longitudinal study.J Mental Health Hum Behav 2017;22:14-20


How to cite this URL:
Nebhinani N, Sharma P, Suthar N. Role of Vitamin D supplementation in patients with depressive disorders and hypovitaminosis D: A longitudinal study. J Mental Health Hum Behav [serial online] 2017 [cited 2020 Nov 27 ];22:14-20
Available from: https://www.jmhhb.org/article.asp?issn=0971-8990;year=2017;volume=22;issue=1;spage=14;epage=20;aulast=Nebhinani;type=0